Latest Articles

  1. Original research

    Impact of Nucleic Acid Testing (NAT) on screening blood donors at a tertiary center in Vietnam

    To K., Lâm T.,ị N.,ọc T.,âm Nguyễn P.,ươn., A., Hồ Tấn T., Lò T.,ị T.,ảo N.,ên Cai T.,ị T., N.,ân Phù C.í Dũn.
    To ensure safe blood transfusion, since June 2015, Nucleic Acid Testing (NAT) technique has been applied in blood screening process in some areas in Vietnam. The objective of our project is to examine the effectiveness of this technique, to provide specific, updated evidence, as the fundamental for promoting the application of NAT technology in screening blood donors. The study describes a series of cases, performed on 412,705 blood donated samples meeting inclusion criteria at Blood Transfusion Hematology Hospital from January 1, 2017 to January 1, 2019. All collected blood samples were screened for HBV, HCV, and HIV by serology technique, then samples with negative results will continue to be screened by NAT technique. Test results and donor information will be stored on the the hospital’s database. As a result, thanks to NAT screening, our study found 369 more positive blood samples with viral genetic material that serology did not detect, of which: 352 samples reacted with HBV-DNA (0.0871%), 10 samples responded to HCV-RNA (0.0025%) and 6 samples responded to HIV-RNA (0.0017%). Therefore, the application of NAT to the blood screening process is necessary to improve the safety of blood transfusion. Regarding the characteristics of positive cases with infectious agents, we recorded a higher rate of positive for HBV, HIV than men, even when tested by serology or by NAT technique (statistically significant, P <0.05); The positive rate for these 3 agents was higher for first-time blood donors than for repeat blood donors, statistically significant with serological screening (P <, 001) and not statistically significant when screening NAT (P> 0.05). In conclusion, The application of NAT technology in blood screening is essential and effective, improving blood transfusion safety.
    Published: 2020-11-17Online First
  2. Original research

    An optimized method for detection of MECP2 point mutations in Vietnamese children with rett syndrome

    LÊ VÂN LÊ DƯƠN., ĐỖ HẰN., HUỲNH K.,ỀU NGUYỄN LÊ H.,ẾU BÙI D., NGUYỄN VŨ NGUYỄN DŨN., HUYNH H.
    Rett syndrome is a rare disease but affecting severe brain dysfunction. The rate of the syndrome is estimated to be 1/10,000–1/15,000 female births. This disorder is knowledge caused by de novo mutations in the MECP2 gene. More than 80% of patients with Rett syndrome have a point mutations in MECP2. The study correlation genotype-phenotype open to therapeutic opportunities for patients. In Vietnam, to validate the diagnosis, the doctors are mainly clinical diagnostic standards, not include genetics testing. Therefore, optimize the producer to determine MECP2 variations is necessary that provides evidence for clinical diagnosis, supporting the earlystage diagnosis of pediatric patients.
    Published: 2020-11-1027-34
  3. Original research

    Pancytopenia in children at hematology department, children hospital 1: clinico-haematological profiles and bone marrow examination – a case series

    Duong M., Thanh An D., T., My L.
    To determine causes of pancytopenia in children via bone marrow aspiration at Hematology Department, Children hospital 1; clinical characteristics, time to diagnostic; peripheral blood smear and bone marrow examination.
    Published: 2020-10-2318-26
  4. Original research

    Histopathological features of chronic periapical lesions

    Pham D., L., Vo T., Nguyen K. C.
    Chronic periapical inflammation, the sequela of necrotic pulp, is one of the most common diseases in dental practice. The diagnosis of these lesions is based on clinical presentation, radiological features and histopathological examination. The aim of this study was to evaluate the clinico-pathological features of chronic inflammatory periapical lesions. 92 periapical lesions were collected at HCMC Odonto-Stomatology Hospital and HCMC National Odonto-Stomatology Hospital at HCM from June 2019 to January 2020. Male to female ratio was 1:1.6, the age range was 10-70 with average age was 35.5 years old. In terms of clinical features, 30.4% of patients were asymptomatic, 28.3% had percussion sensitivity, 27.2% had swelling, 12% had cortical expansion, 18.5% had intraoral fistula and 3.3% had tooth mobility. The most frequently- involved locations were the anteria maxilla and posterior mandible. Histopathological results confirmed 49 radicular cysts and 43 periapical granulomas. In most cases of radicular cyst (47 cases, 96%), the cyst was lined with nonkeratinized stratified squamous epithelium, with two cases containing mucous cells, 3 cases were observed with cholesterol clefts and 3 cases with Hyaline bodies. In 43 cases of periapical granulomas, the lesions included chronic inflammatory cells and 3 cases with cholesterol clefts. The collagen fibers in fibrous stroma of radicular cysts appeared to be thicker and more linearly arranged while they seemed to be thinner in scattered pattern in periapical granulomas. There was no significant difference between the prevalence of radicular cysts (53.3%) and periapical granulomas (46.7%), no case of chronic periapical abscess was recorded. The ratio of radicular cysts (67.3%) was significantly higher than periapical granulomas (41.9%) at the posterior areas (p<0.05).
    Published: 2020-09-069-17
  5. Original research

    The total oxidant status and total antioxidant capacity of saliva in patients with chronic periodontitis before and after non – surgical periodontal treatment

    Nguyễn L., Võ T.,ùy Nguyễn T.ủy
    The aim of this study was to measure the total oxidant status (TOS) and total antioxidant capacity (TAOC) levels in the saliva of patients with chronic periodontitis, before and after non – surgical periodontal treatment (NSPT). In addition, we aimed to investigate the correlation between salivary TOS, TAOC levels and periodontal parameters.
    Published: 2020-08-131-8

Submit an Article


Updates
Feeds