Latest Articles

  1. Original research

    Formulation of virgin coconut oil microemulsion with natural excipients

    Pham N., Le Q., Vo N., Nguyen N.,-S., Le T., Tran T.
    Virgin coconut (Cocos nucifera (L.)) oil (VCO) is taking attention from re-searchers because of its biological activities. However, applying VCO directly on the skin often leaves an uncomfortable feeling of greasy, clogged pores and difficult to wash. Coco-nut oil in microemulsion is a better option since it can increase bioavailability as well as convenience for users. Furthermore, this study aims to use natural ingredients, safe for the skin and environmentally friendly.
    Published: 2023-01-20In press
  2. Systematic review

    Small molecules as anti COVID-19 therapeutics: Discovery process, mechanism of action and clinical trials

    Mai T.,àn., Tấn Lâm T.,ừa P., Đặng Bảo N.,ọc T.,ân Lại Võ T.,ọn., N.,ĩa Thái K.,ắc M., Trần T.,àn., Đạo Nguyễn M., H.,ền Nguyễn P.,ước V., Lê M. T.í
    COVID-19 has become a pandemic and is still breaking out in many countries all over the world due to the emergence of new variants. Several safe and effective vaccines have been approved and succeeded in reducing the rate of patients with severe symptoms and that of mortality. Currently, most countries have chosen to change their policy from “zero Covid” to “live with” the pandemic and opened their boundaries to recover their economy. However, the emergence of new dangerous variants such as Delta or Omicron significantly reduces the effectiveness of vaccines and therefore, is complicating the pandemic control. In addition to the use of vaccines, the development of antiviral drugs is extremely important to tackle this worldwide threat. Currently, the approved anti-COVID-19 agents consist of two main categories, including spike protein (S) targeted monoclonal antibodies and orally available small molecule antiviral agents. However, the biopharmaceutical approach still incurs significant drawbacks such as bad bioavailability, expensive and growing resistance of the virus due to the accumulation of mutations in the receptor binding domain (RBD) of the spike protein in new variants. On the other hand, small molecule antiviral agents are a more appealing approach as their main therapeutic targets are intrinsic enzymes which are less likely to mutate, hence remaining inhibitory activity against different variants. Additionally, the oral availability of these drugs also allows these medications to be taken by individuals without the aid of healthcare professionals, which could alleviate the burden on healthcare systems. Therefore, the research and finding of new orally available antiviral agents is still a necessity. This review is carried out to give an overview of the discovery and development, mechanism of action, clinical trials, and approval status of current small-molecule anti-SARS-CoV-2 drugs.
    Published: 2023-01-15In press
  3. Original research

    Quality of life of COVID-19 patients after treatment at Thu Duc City Hospital

    Trần Đặng V., Nguyễn Ân Lê N.àn
    To determine the average quality of life score and the relationship between the quality of life score of COVID-19 patients after treatment at Thu Duc City Hospital with socio-demographic characteristics and historical treatments.
    Published: 2022-12-16In press
  4. Original research

    Changes of hematological and biochemical parameters in psoriasis patients treated with Secukinumab

    Tuyến H.,àn., T.,ị Hào N.ễn
    Psoriasis is a chronic inflammatory disease, not just affecting skin and joints but also associated with the development of cardiovascular diseases, metabolic sydrome. Secukinumab is demonstrated highly effective in the treatment of psoriasis, but so far, there has been few research on the effect of secukinumab treatment on hematological and blood biochemistry parameters in psoriasis patients. The correlation between the change of these parameters and the change of clinical outcomes are aslo evaluated.
    Published: 2022-12-16In press
  5. Original research

    Characteristics of skin damages by using face masks and related factors in patients visited to Ho Chi Minh City hospital of Dermato-Venereology

    Trang H.,ỳn., Hào N.ễn
    Long-term mask use can lead to skin reactions, such as itching, allergic dermatitis, irritant contact dermatistis, increased sebum secretion, acne formation or increased existing acne. Currently, there are many researches on the affection on skin of persional protective equipment for Covid-19 in general and face masks in detail. To our best knowledge, there has been no studies about this issue in Vietnam up to now. Objectives: This study aims to evaluate clinal characteristics of skin damage by using face masks and related factors on patients visited the Ho Chi Minh City Hospital of Dermato-Venereology.
    Published: 2022-12-16In press
  6. Original research

    Prevalence of anxiety disorders and associated factors among students of School of Medicine – Vietnam National University Ho Chi Minh City

    Nguyễn Ân Hoàng N.,ọc Nguyễn N.,ọc Võ N.,ĩa Bùi M., Lê Mỹ Nguyễn Dũn.
    The research was conducted with the purpose of estimating the prevalence of Anxiety Disorder and associated factors among students of School of Medicine – Vietnam National University Ho Chi Minh City.
    Published: 2022-12-15436-442
  7. Original research

    Research on clinical characteristics and clinical healing assessment after endodontic surgery using ultrasonic tip and root -end filling material by MTA

    Bui C., Bich L., Hien H.
    Endodontic surgery is one of the tooth-conserving interventions indicated when conventional endodontic treatment fails for teeth with periapical lesions with the conventional classical method using handpiece with drill for osteotomy, apectomy, sinus creation and retrograde filling with Amalgam. Today, many studies have shown that when applying improvements in surgery such as the use of ultrasonic instruments for osteotomy, apectomy, sinus creation and retrograde filling with biomaterial Mineral Trioxide Aggregate (MTA) helps to reduce pain and swelling, to increases the clinical healing rate after surgery, thereby contributing to increase the success after intervention. Objectives: To investigate the clinical outcomes and evaluate clinical healing after endodontic surgery using ultrasound instruments and retrograde fillings with MTA materials.
    Published: 2022-12-15443-451
  8. Original research

    Efficiency of guided bone regeneration in vertical bone augmentation with titanium-reinforced PTFE membrane and platelet-rich fibrin

    Cao D., Vo T., Vo H., Pham L., Dau L., Le L.
    Guided bone regeneration (GBR) for vertical bone augmention is an easy-to-implement approach and has a good prognosis. However, there are many different procedures that lead to different clinical outcomes. The use of platelet-rich fibrin (PRF) can improve outcomes in regenerative treatments. Therefore, this study aimed to evaluate the effectiveness of vertical bone grafting by guided bone reconstruction with titanium-reinforced PTFE membrane combined with PRF.
    Published: 2022-12-15452-460
  9. Original research

    Changes of alveolar ridge dimension after autogeneous mandibular bone augmentation with split bone block technique

    Bùi Lâm Phạm L., Võ N.,ân Võ Hùn., Đậu Lượn., Võ T.,ỳ Lê Lán.
    the aim of study is to evaluate the changes of alveolar rigde dimension after split bone block technique with autogenous bone block graft from mandible on CBCT.
    Published: 2022-12-15461-469
  10. Original research

    Antibiotics prescribed by dentists in Ho Chi Minh City, Vietnam

    Trần L.,ên Huy N., P., Điền Vũ Võ T.ến
    A study aims to evaluate the current use of antibiotic prescribing by dentists in Ho Chi Minh City. The prospective study collected data from 73 dentists working in Ho Chi Minh City from March to September 2022 using a questionnaire based on the online tool Google Form, including general information about dentists, patients’ infection condition, and photocopies of prescriptions. A total of 458 prescriptions was obtained. The number of prescriptions related to dental infections was 312 (68.1%), and more than 130 (28.4%) were related to procedures/surgery. Prophylactic antibiotics were indicated after interventions. The most commonly prescribed antibiotic is spiramycin combined with metronidazole (39.5%), followed by co-amoxiclav (33.8%) and amoxicillin (11.8%). Most dentists prescribed antibiotics based on their knowledge and experience (87.7%). Most of the doses, dose intervals, and duration of antibiotic use prescribed by the participants in the study were consistent with the manufacturer’s recommendations and current guidelines. However, prophylactic antibiotics are recommended to be prescribed before the interventions; single antibiotics are preferred over combination antibiotics in treating oral infections. The current situation of antibiotic prescribing in Ho Chi Minh City still has some inconsistent points compared to recommendations and guidelines. Because the species of bacteria causing the disease and the situation of susceptibility/resistance vary from place to place, further evaluation studies are needed to aim at the safe and effective use of antibiotics.
    Published: 2022-12-15470-480

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