Latest Articles

  1. Original research

    Comparison of platelet rich fibrin and guided tissue regeneration in the treatment of periodontal intrabony defects

    Pham T.
    Aim: To compare the outcomes of the treatment of periodontal intrabony defects with platelet-rich fibrin (PRF) combined with open-flap debridement (OFD) and guided tissue regeneration (GTR). Material and method: Thirty individuals with a total of 60 intrabony defects were randomly assigned to one of the 2 treatment groups: group 1 (n=30): OFD combined with PRF and group 2 (n=30): guided tissue regeneration with collagen membrane. Clinical parameters, including the plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment loss (CAL), and tooth mobility (TM) were assessed at baseline, 3, 6 and 12 months postsurgery. Radiographic parameters, including bony defect fill (BDF) and alveolar crestal resorption (ACR), were measured at baseline, 6 and 12 months postsurgery and calculated using Sopru imaging 2.38 software. The wound healing index (WHI) was assessed at 7 and 14 days postsurgery. Results : There was a statistically significant improvement in clinical periodontal and radiographic parameters at 6 and 12 months postsurgery in both groups. Between the two groups, the improvement of these parameters was similar, the difference was not statistically significant at 6 and 12 months postsurgery. Both groups had percentages of sites with the wound healing score of 1 between 81% and 100%, but group 1 had a significantly greater number than group 2 at 7 and 14 days postsurgery. Conclusion: latelet-rich fibrin combined with open-flap debridement and guided tissue regeneration with collagen membrane were similarly effective in treatment of periodontal intrabony defects. Using PRF improved better postoperative healing compared to guided tissue regeneration with collagen membrane.
    Published: 2021-05-09162-170
  2. Original research

    Clinical efficacy of enamel matrix derivative in treatment of periodontal intra-bony defects

    Nguyen N., Nguyen T., Pham T.
    The adjunctive use of EMD enhances the efficiency of OFD in treatment of periodontal intra-bony defects because reducing periodontal pocket depth, clinical attachment loss, and gingival recession.
    Published: 2021-05-04155-161
  3. Original research

    Using sodium dithionite as a reducing agent in the synthesis of propacetamol hydrochroride from phenol

    Nguyen H., Huan L., Khanh T., Lan N., Phuc N., Thien N., Phuong B., Diem T., Ngan T., Thang P., Hung T., Tri L., Nguyen V.
    Propacetamol, a prodrug form of paracetamol, is used in injections for fast and effective pain relief. Propacetamol is water soluble and is used in postoperative care as well as intravenous administration in case the patients cannot take oral or rectal paracetamol. Studies on propacetamol synthesis at laboratory scale as well as industrial scale with safe, simple and economic procedures are crucial. In this study, we synthesized propacetamol from phenol as the starting material. In the first step, phenol was converted to p-nitrosophenol through a nitrosation process. This nitrosation reaction yielded the optimal result as the reaction selectively occured, the product was not plasticized. Next, p-nitrosophenol was reduced to p-aminophenol in the presence of sodium dithionite as the reducing agent. The reaction produced p-aminophenol at a yield of 89,6% with high selectivity and less impurity. After that, paracetamol was obtained through acetylation of p-aminophenol. Ochloroacetylation of paracetamol was performed by using the amount of diethylamine reduced by 2,5 times compared to previous studies to form 4-acetamidophenyl-2-chloroacetate in 85,5% yield. This intermediate was then alkylated to form propacetamol base, followed by treatment with HCl solution in acetone at low temperature to obtain propacetamol hydrochloride in 32,5% yield. The study has shown that propacetamol hydrochloride was successfully achieved with high efficiency and safety from phenol as the starting compound.
    Published: 2021-04-30147-154
  4. Systematic review

    Updating recommendations for prescribing antibiotics in dental practice

    Huy N., P., Lien T.
    According to World Health Organization, antibiotic resistance is one of the alarming global issues requiring the collaboration of different human resources, including clinicians. Based on some countries' recent survey results, there is an increased rate of prescribing antibiotics in dental practice (20%), and most of them are often unnecessary (80%). Some reasons could be cited here are (1) the appearance of some new dental treatments having prophylactic antibiotics, (2) an increase of the aging population, and (3) dentists may be more likely to prescribe an antibiotic while patients wait for the main intervention, etc. Due to this situation, many international and national dental organizations have developed specific recommendations related to the indication and utilization of antibiotics in dental practice. In Vietnam, although there were several alerts and studies concerning antibiotic resistance in dentistry, official and national recommendation has not presented yet. This review aims to synthesize and compare the recommendations of antibiotics prescription in the dental practice of credible professional organizations in certain developed countries in the period of ten years (2011-2020). Besides, we suggest several research directions to provide further scientific evidence to establish specific guidelines for Vietnam's circumstances and improve antibiotic resistance and the community's oral health.
    Published: 2021-04-25134-146
  5. Narrative review

    Role of fluid biomarkers in the early diagnosis of Alzheimer’s disease

    Vo G., Nguyen M., N., Vo T.
    Alzheimer’s disease (AD) is the most common form of dementia in the elderly, which is clinically characterized by the progressive deterioration of memory and other cognitive functions that results in the loss of autonomy and ultimately leading to death. Increasing life expectancy has resulted in AD becomes a global public health concern, especially in developing countries as Vietnam. While there is currently no effective treatment for the disease, early detection of AD is critical to slow disease progression, prevent long-term morbidity and mortality, as well as reducing healthcare spending. The diagnosis of AD currently relies on clinical criteria, including mental status assessment, neurological examination, and brain imaging tests. However, these imaging methods are conclusive only in the advanced stages of disease, whereas AD physiopathology begins several decades before onset of the first symptoms. It is therefore particularly important to identify potential biomarkers that can be used in the early detection of AD aim to evaluate the efficiency of therapeutic agents under testing and to thus accelerate the therapeutic discovery process. The aim of the review was to highlight the current knowledge as well as future perspectives on the role of biomarkers in screening, diagnosis, treatment and follow-up of Alzheimer’s disease.
    Published: 2021-04-15122-133
  6. Original research

    Effect of prf on pain and swelling after surgical removal of impacted lower third molars

    Lam P., Ly N., Ngoc N.
    The aim of this study is to evaluate the effect of PRF on reducing pain, swelling after surgical removal of impacted lower third molars.
    Published: 2021-04-15102-109
  7. Original research

    Up-regulation of SET nuclear proto-oncogene is associated with early recurrence and poorer prognosis of hepatocellular carcinoma

    Nguyen G., Tran M., Nguyen L., Quynh H., Nguyen M. N.
    Hepatocellular carcinoma is a complex disease and has a high mortality rate. Identifying biomarkers that can use to diagnose early and prognosis of HCC is essential to reduce the burden of HCC on patients, families, and society.
    Published: 2021-04-15110-121
  8. Case Reports

    A novel KCNQ2 gene mutation in a patient with self-limitted non-familial neonatal epilepsy: a case report

    NGUYEN T., H., NGUYEN Q., M., LE K., V., LE M., T., LE A., N., DO H., HUYNH H., DO T. H.
    This study reported a rare case of self-limited non-familial neonatal epilepsy with a novel KCNQ2 gene mutation. It should be cautious that some patients with KCNQ2-self-limited non-familial neonatal epilepsy may present some features resembling epileptic encephalopathy at onset/early stage. The complex genotype–phenotype correlation of KCNQ2-related epilepsies and the genetic counselling involved with the case are also discussed in this case report.
    Published: 2021-02-2194-101
  9. Original research

    High expression of DIMT1 correlates with poor prognosis and high risk of bone metastasis in breast cancer patients

    Tran H., Vo T., Nguyen M. N.
    DIMT1 is a potential predictor in gaining insights into the heterogeneous landscape of bone metastatic. Moreover, by integrating into the molecular subtypes, DIMT1 can further subclassify patients into two risk groups, thereby enabling more informed therapeutic decisions and improved prognostics for breast cancer. Together, these findings indicate the general utility of DIMT1 as a biomarker in the age of personalized and precision medicine.
    Published: 2021-02-0852-63
  10. Original research

    The effect of 1% povidone iodine and 0,75% boric acid on chronic periodontitis treatment

    Pham T., Tran Q.ên
    To evaluate the effect of 0,75% boric acid or 1% povidone iodine irrigation an adjunct to scaling and root planning (SRP) in treatment of chronic periodontitis patients.
    Published: 2020-12-3175-85

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