Latest Articles

  1. Original research

    Evaluation of internal reliability and EFA analysis of students' satisfaction on Dental education program - University of Medicine and Pharmacy at Ho Chi Minh City

    Tran T., Hoang Dao B., T., Nguyen Thi T., Q., Le Ba A. D.
    Surveying learners’ opinions is one of the crucial data channels in the accreditation and quality assurance of education and training, serving as a database to help training programs consider quality improvements. Since 2019, the University of Medicine and Pharmacy at Ho Chi Minh City has conducted surveys on the satisfaction levels of graduating students regarding the quality of training programs in all undergraduate programs. However, the survey sample has not yet been statistically evaluated for internal reliability and the grouping of survey questions. In this study, the survey results of Dental programs (Dental Surgery and Dental Prosthetics programs) were used as a representative sample for statistical analysis using Cronbach’s Alpha and Exploratory Factor Analysis (EFA). The results showed that the number of survey samples collected (115 samples) met the sampling requirements. The survey questions had high Cronbach’s Alpha coefficients (above 0.8). The EFA analysis suggested regrouping the questions into three main survey groups: Quality of the training program, Quality of the teaching staff – training organization, and Quality of student support activities. This research result will serve as a basis for improving the survey model used for all other training programs at the University of Medicine and Pharmacy at Ho Chi Minh City in the coming years.
    Published: 2024-09-21In press
  2. Original research

    The relationship between risk habits, oral hygiene status, and the effectiveness of radiation-induced oral mucositis treatment

    Le T., Nguyen C., Tran H., Vo T.
    To determine whether there is a relationship between risk habits, oral hygiene status, and the effectiveness of radiation-induced oral mucositis treatment.
    Published: 2024-09-21In press
  3. Original research

    Microbiological profile and antibiotic utilization patterns in nosocomial pneumonia: a cross-sectional study in the intensive care unit of Thong Nhat Hospital

    Nguyen U., Le A., Huynh T., Bui Q., Pham H.
    The objective of this survey was to investigate the microbiological characteristics and antibiotic usage patterns in the treatment of hospital-acquired pneumonia (HAP) patients in the Intensive Care Unit (ICU) setting.
    Published: 2024-09-16In press
  4. Narrative review

    Overview of Dravet syndrome and an update in therapeutics

    Do H.
    Dravet syndrome is a developmental epileptic encephalopathy characterized by early onset drug-resistant seizures and other clinical features, including intellectual disability and impairments in behavior, motor, and sleep which cause poor quality of life and impact the long-term course. The pathogenesis of Dravet syndrome is strongly connected to the dysfunction of the voltage-gated sodium channel, more specifically, to mutations in SCN1A gene. Epilepsy in Dravet syndrome is very refractory and seizures remain poorly controlled even with multiple conventional anti-epileptic drugs. Therapeutic approaches in Dravet syndrome have undergone tremendous changes in the lastest years and the current consensus of seizure management strategy in Dravet syndrome consists of a combination of conventional drugs and three recently approved drugs including stiripentol, cannabidiol, and fenfluramine. This review article aims to update recent changes to the therapeutic landscape for Dravet syndrome by summarizing the most key data from the clinical development of stiripentol, cannabidiol, and fenfluramine. This article also reviews and discusses the latest findings of other pharmacotherapies in development, including serotonergic agents, soticlestat, verapamil as well well strategies to treat the underlying cause of Dravet syndrome, including gene therapy and antisense oligonucleotides.
    Published: 2024-06-30633-643
  5. Original research

    The characteristics of clinical, microbiological and antibiotic resistance profile in patients with bacterial keratitis at Ho Chi Minh City Eye Hospital in 2020

    Tran B., Lê H., Phan A., Pham H., Nguyen L., Tran P., Pham H.
    Purpose: To investigate the epidemiological, clinical, microbiological characteristics and antibiotic resistance profile in patients with bacterial corneal ulcers at Ho Chi Minh City Eye Hospital in 2020. Methods: An observational retrospective study was conducted on 242 cases diagnosed with bacterial corneal ulcers examined at Ho Chi Minh City Eye Hospital from January 2020 to December 2020. Information about patients’ medical history, clinical symptoms, and test results was collected from medical records. Results: Bacterial keratitis was more often seen in males and in middle-age group. Injury as a risk factor accounted for a considerable proportion of cases (24,4%). Self-treatment was common (23,1%). The culture results were mainly Gram-positive (56,6%), in which coagulase-negative staphylococci (49,2%) predominates. Pseudomonas aeruginosa (26,9%) was the most common Gram-negative pathogen. The resistance rate of coagulase-negative staphylococci to common antibiotics, including fluoroquinolones group, was relatively high (50,0 – 100,0%). Meanwhile, P.aeruginosa was sensitive to many fluoroquinolones, as well as to tobramycin and ceftazidime. Notably, we recorded twelve cases of resistance to all tested antibiotics. The rate of visual acuity improvement at the time of discharge was still unfavorably low (5,8%). There were 43,0% of patients experiencing at least one serious complication: increased intraocular pressure, endophthalmitis, impending perforation and perforation of the cornea. Up to 11,6% of patients had to resort to enucleation. Conclusions: Corneal ulceration related to trauma accounted for a significant percentage. Self-medication was still common. The high rate of antibiotic resistance along with the appearance of numerous multi-drug resistance cases is very worrying. Severe consequences were left upon patients’ eyesight.
    Published: 2024-06-30624-632
  6. Original research

    The relationship between traditional medicine constitutional types and dysmenorrhea in female students at the Faculty of Traditional Medicine at University of Medicine and Pharmacy at Ho Chi Minh City

    Le H., Pham T., Bùi M. C.âu
    Dysmenorrhea is a prevalent health issue that significantly affects the quality of life for women in their reproductive years, particularly among female students studying traditional medicine. These individuals, given their specific learning and living conditions, are at an elevated risk of experiencing menstrual pain. Traditional Medicine emphasizes the connection between dysmenorrhea and an individual's body constitution. Recognizing and adjusting one's body constitution can be beneficial in both preventing and supporting the treatment of this condition. This study aimed to investigate the relationship between the traditional medicine constitutional types and dysmenorrhea in female students at the Faculty of Traditional medicine at University of Medicine and Pharmacy at Ho Chi Minh City.
    Published: 2024-03-10619-623
  7. Original research

    Stromal CD10 expression in ameloblastomas: Correlation with clinical, radiographic and histopathologic characteristics

    Vo T., Nguyen C.
    There were significant association between stromal CD10 expression and clinical, radiographic and histopathologic characteristics of ameloblastomas. Expression CD10 by stromal cells might be correlated to local invasion of ameloblastomas.
    Published: 2023-12-31601-610
  8. Original research

    Optimizing Fiber Laser Ablation for Enhancing the Tumor Microenvironment in Neuroblastoma

    Nguyen G., Nguyen K., Nguyen Q., Pham C., Bui B., Nguyen B.
    Neuroblastoma (NB) is a type of cancer that often affects children. Surgical management of smaller tumors (those less than 5 cm in size) poses unique challenges, making it difficult to ensure thorough and effective treatment. The primary aim of our study is to develop and optimize a model for laser ablation specifically tailored for small NB tumors.
    Published: 2023-12-31611-618
  9. Original research

    Optimisation of a floating tablet containing clarithromycin 500 mg

    Cao T.,ị T., T.,ảo Nguyễn N.,ọc T., P.,ươn., Trần Văn T.,àn., Hoàng M., C.,âu Nguyễn N.ọc K.ôi
    The purpose of the research is to optimize the formulation of a gastric floating drug delivery system of clarithromycin 500 mg (CLA). CLA is a macrolide antibiotic, indicated in the treatment of sinusitis, pharyngitis, pneumonia, acute and chronic bronchitis, especially in the treatment of Helicobacter pylori (H. pylori) infection. The formulation design is retained in the stomach for prolonging the floating time to improve bioavailability, drug absorption. The excipients include polymers such as hydroxypropyl methyl cellulose (HPMC) to control drug release. Besides, sodium bicarbonate is generally used in pharmaceuticals as a source of carbon dioxide in effervescent tablets – has been used as a gas-forming agent in floating to prolong floating time and reducing gastric irritation. Preformulating testing is not the interaction between the ingredients together. In vitro floating time and vitro dissolution studies were carried out that the results of the best formulation with HPMC K100M, HPMC K15M and NaHCO3 are 22%; 12.5% và 14.7% based on concentrate of CLA. The formulations were designed by Design - Expert and BCPharsolf OTP. The result of research showed that the floating time is approximately 8.53 – 9.34 hours and drug release for 12 hours, respectively 25% (after 2 hours), 20 – 40% (after 4 hours) and over 80% (12 hours). The analytical method for determination and quantification of CLA such as high-performance liquid chromatography (HPLC) and Fourier transform infrared FTIR.
    Published: 2023-06-30567-577
  10. Case Reports

    Uterine leiomyoma in a 14 – year – old girl: Case report and literature review

    Toàn P.,ạm Huệ Võ Hưng N.ễn
    Uterine leiomyomas are benign tumors arising from the smooth muscle cells of the uterus or extracellular matrix, that are very common among women of reproductive age between 30 and 50 years of age. However, their incidence is extremely rare in women under 15-year-old (<1%) with unknown etiology. Ultrasound and magnetic resonance imaging (MRI) comfirms the location, number, size of mass, which plays an important role in prognosis and treatment. Leiomyomas have been managed in a variety of methods and are considered to decide the most optimal way to preserve fertility in adolescents.
    Published: 2023-06-30578-583

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