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Abstract

Objectives: The objective of this survey was to investigate the microbiological characteristics and antibiotic usage patterns in the treatment of hospital-acquired pneumonia (HAP) patients in the Intensive Care Unit (ICU) setting.


Materials and methods: A cross-sectional study analyzed 83 medical records of patients diagnosed with hospital-acquired pneumonia and ventilator-associasted pneumoniae. The study took place from January to December 2022 in the Intensive Care Unit of Thong Nhat Hospital. Data included epidemiological characteristics, causative pathogens, prescribed antibiotics.


Results: Gram-negative bacteria, particularly Acinetobacter baumannii (26.1%), Klebsiella pneumoniae (21.8%), and Pseudomonas aeruginosa (19.3%), were the predominant isolates. The susceptibility of Acinetobacter baumannii and Pseudomonas aeruginosa to all antibiotic groups was significantly low, below 50%. The susceptibility of Klebsiella pneumoniae was also low for all antibiotic groups, with rates below 30%, except for colistin (87.5%) and gentamicin (66.7%). The majority of patients received combination therapy with three or more antibiotics, accounting for 72.1%. Colistin was the most frequently prescribed antibiotic at a rate of 63.3%, followed by carbapenems including meropenem and imipenem, with rates of 30.1% and 20.4% respectively. The rate of antibiotic resistance in Methicillin-resistant Staphylococcus aureus (MRSA) was also relatively high, with linezolid at 51%, teicoplanin at 11.7%, and vancomycin at 6.1%.


Conclusions: To prevent the emergence of antibiotic resistance in hospital-acquired pneumonia, it is essential to prioritize the implementation of infection control measures and ensure the responsible use of antibiotics in treatment.



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Article Details

Issue: Vol 2024 No Online First (2024): Online First
Page No.: In press
Published: Sep 16, 2024
Section: Original research
DOI:

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Copyright: The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 How to Cite
Nguyen, U., Le, A., Huynh, T., Bui, Q., & Pham, H. (2024). Microbiological profile and antibiotic utilization patterns in nosocomial pneumonia: a cross-sectional study in the intensive care unit of Thong Nhat Hospital. Science and Technology Development Journal: Health Sciences, 2024(Online First), In press. Retrieved from https://stdjhs.scienceandtechnology.com.vn/index.php/stdjhs/article/view/578

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