VNUHCM Journal of Health Sciences <p><strong>The Science and Technology Development Journal - Health Sciences (STDJ-HS) (ISSN&nbsp;2734-9446)</strong> is an international, open access, and peer-reviewed journal published by School of Medicine, Vietnam National University Ho Chi Minh City. The journal publishes researches in the fields of medicine, pharmacy, dentistry, public health, traditional medicine, nursing, and medical technology. Relevant articles from other disciplines of health professions may be considered for publication. However, the journal places an emphasis on publishing high-quality, high-impact and novel research. Articles can be submitted in the in the form of original research articles, reviews, case reports, commentaries or letters to the editor. We accept manuscripts in both English and Vietnamese.</p> <p><span id="result_box" class="" lang="en"><span title="Tạp chí đã trải qua 20 năm phát triển và đã trở thành nhịp cầu giao lưu khoa học, cũng như làm phong phú tài liệu tham khảo cho đội ngũ giảng viên, nghiên cứu sinh, sinh viên ĐHQG-HCM nói riêng và các Trường đại">&nbsp;</span></span></p> <p>&nbsp;</p> <p><span class="" lang="en"><span title="Tạp chí đã trải qua 20 năm phát triển và đã trở thành nhịp cầu giao lưu khoa học, cũng như làm phong phú tài liệu tham khảo cho đội ngũ giảng viên, nghiên cứu sinh, sinh viên ĐHQG-HCM nói riêng và các Trường đại"><span id="result_box" class="" lang="en"><span title="Tạp chí Phát triển Khoa học và Công nghệ (PTKH&amp;CN) của Đại học Quốc gia thành phố Hồ Chí Minh (ĐHQG-HCM) được thành lập từ năm 1997, ra số đầu tiên vào tháng 1 năm 1998. Từ năm 2006 Tạp chí đã"><strong>Science and Technology Development Journal - Health Sciences (STDJ-HS) is a subjournal of Science and Technology Development Journal focusing on:</strong><br></span></span></span></span></p> <p>&nbsp;</p> <ul> <li class="show">Publishing articles with contents on healthcare, research projects in the field of health, advanced directions in health education and management. Therefore, STDJ-HS will accept articles from doctors, administrators, teachers, researchers, graduate students and fellows. The authors will be responsible for the accuracy of the data, opinions, opinions and material cited in the article.</li> <li class="show">Facilitating the exchange of scientific and technological information and act as a bridge between theory and practice in the community of educators, scientists, managers, policy makers and enterprises in and out of the country.</li> </ul> <p><span class="" lang="en"><span title="• Khoa học Trái đất và Môi trường"><span id="result_box" class="" lang="en">&nbsp;</span></span></span></p> Viet Nam National University Ho Chi Minh City en-US VNUHCM Journal of Health Sciences 2734-9446 <p>Copyright The Author(s) 2018. This article is published with open access by Vietnam National University, Ho Chi Minh city, Vietnam. This article is distributed under the terms of the&nbsp;<a href="" target="_blank" rel="noopener">Creative Commons Attribution License (CC-BY 4.0)</a> which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.&nbsp;</p> Optimisation of a floating tablet containing clarithromycin 500 mg <p>The purpose of the research is to optimize the formulation of a gastric floating drug delivery system of clarithromycin 500 mg (CLA). CLA is a macrolide antibiotic, indicated in the treatment of sinusitis, pharyngitis, pneumonia, acute and chronic bronchitis, especially in the treatment of Helicobacter pylori (H. pylori) infection. The formulation design is retained in the stomach for prolonging the floating time to improve bioavailability, drug absorption. The excipients include polymers such as hydroxypropyl methyl cellulose (HPMC) to control drug release. Besides, sodium bicarbonate is generally used in pharmaceuticals as a source of carbon dioxide in effervescent tablets – has been used as a gas-forming agent in floating to prolong floating time and reducing gastric irritation. Preformulating testing is not the interaction between the ingredients together. In vitro floating time and vitro dissolution studies were carried out that the results of the best formulation with HPMC K100M, HPMC K15M and NaHCO3 are 22%; 12.5% và 14.7% based on concentrate of CLA. The formulations were designed by Design - Expert and BCPharsolf OTP. The result of research showed that the floating time is approximately 8.53 – 9.34 hours and drug release for 12 hours, respectively 25% (after 2 hours), 20 – 40% (after 4 hours) and over 80% (12 hours). The analytical method for determination and quantification of CLA such as high-performance liquid chromatography (HPLC) and Fourier transform infrared FTIR.</p> Thị Thanh Thảo Cao Ngọc Thanh Phương Nguyễn Văn Thành Trần Minh Châu Hoàng Ngọc Khôi Nguyễn ##submission.copyrightStatement## 2023-05-12 2023-05-12 4 1 press press 10.32508/stdjhs.v4i1.547 title description none g Concordance between HB&L system and conventional culture method for bacterial antibiotic susceptibilities from positive blood samples at Hospital for Tropical Diseases from 03/2020 to 04/2021 <p>Presently, shortening the time-to-result of antimicrobial susceptibility test (AST) is of the utmost importance for sepsis management in an effort to reduce mortality and antibiotic resistance rate. HB&amp;L ((Human Biological Liquid Culture), a product of the Alifax company (Italy), can detect replicating microorganisms and their antibiotic resistance in a few hours with high sensitivity and specificity by using light scattering technique. This study aims to evaluate the correlation between rapid antibiogram using the HB&amp;L system and the routine methods on positive blood cultures at the Hospital for Tropical Diseases in Ho Chi Minh City from March 2020 to April 2021. Gram-positive bacteria blood samples were tested against Cefoxitin, Vancomycin while Gram-negative bacteria samples were trialed with Ceftriaxone, Levofloxacin, Piperacillin-Tazobactam and Meropenem. The concordance of the two methods was defined by the categorical agreement (CA), very major errors (VME), major errors (ME) and minor errors (mE) in Cumitech 31A. Of the 81 blood culture samples containing Gram-negative bacteria, the CA of Ceftriaxone, Meropenem, Levofloxacin and Piperacillin-Tazobactam were 90%, 100%, 67% and 88%. The maximum VME was 22% for Levofloxacin. On the other hand, of the 32 Gram-positive samples, CA and VME of Cefoxitin were 53% and 65% respectively while CA of Vancomycin was 100%. The median time to receive rapid AST results of the HB&amp;L system is 4.43 hours faster than the standard that.</p> Nhu Nguyen Ngoc Quynh Diem Nguyen Co Song Hoang Xuan Duy Nguyen Khanh Diem Le Thi Lan Nguyen Phu Huong Hanh Nguyen Ho Hong ##submission.copyrightStatement## 2023-05-15 2023-05-15 4 1 press press 10.32508/stdjhs.v4i1.525 title description none g Factors influencing students’ satisfaction towards online learning platforms at the VNU-HCM School of Medicine <p>This study investigates the factors affecting students’ satisfaction towards the online learning platform at the School of Medicine, VNU-HCM, by conducting a survey with 268 undergraduate students who have utilized Quickom and Microsoft Teams. The study employed SPSS 20.0 software to assess the reliability of using Cronbach's Alpha, the exploratory factor of EFA, the correlation, the multiple linear regression and ANOVA. The results from Quickom analysis showed that all of five independent factors in the model had a statistically significant impact on students’ satisfaction from high to low, including the perception of the usefulness (beta = 0.331), the convenience (beta = 0.279), the platform quality (beta = 0.242), the ease of use (beta = 0.118), and the technical barriers (beta = -0.114). The results from ANOVA analysis showed that there was no significant difference in the evaluation criteria between Microsoft Teams and Quickom. This study is hoped to serve as a Vietnamese additional source related to students’ satisfaction about online learning flatform and the field of medical student online training. Therefore, it helps policy makers and administrators to compile development strategies more concisely and effectively in accordance with the future trend of technology development.</p> Dung Hoang Nguyen Phu Vinh Vien Kiet Tuan Nguyen Phuong Hoang Nguyen ##submission.copyrightStatement## 2023-05-11 2023-05-11 4 1 press press 10.32508/stdjhs.v4i1.522 title description none g In vivo evaluation of floating tablet clarithromycin 500mg <p>Floating drug delivery system (FDDS) containing Clarithromycin 500mg (CLA) designed to prolong the retention time in the stomach is also an approach to optimize the plasma CLA concentration in the gastric. However, the development of FDDS meets many obstacles about physiology such as cannot control and locate FDDS in gastrointestinal because of the process of stomach emptying. CLA is rapidly absorbed from the gastrointestinal tract, bioavailability in intact form is only about 55% with a relatively short half-life, about 5-7 hours when taking a 500mg dose. Therefore, this research approaching a dosage form CLA to prolong the gastric retention time by in vivo in living body is local dog because the test subject is a dog beagle because anatomically it is quite similar in size to the gastrointestinal tract with the human model. The technical to show CLA image in vivo by X - ray method each time before and after oral administration of a pill and finished until there is no more pill images in the stomach. In addition, plasma drug concentrations were also calculated at each time point using the HPLC with LCMS IT-TOF method and compared with tablets without buoyancy properties. Results of research FDDS containing CLA has been the floating tablet time is 3,5 to 4,5 hours. And plasma concentration between testing group reached at 6 and 8 hours (1964,00 ± 104,25 ng/ml and 1203,00 ± 191,68 ng/ml); and the drud’s peak group reached at 2,5 -3 hours (1169,88 ± 109,42 ng/ml and 1982,63 ± 266,48 ng/ml), respectivety.</p> Thị Thanh Thảo Cao Ngọc Thanh Phương Nguyễn Thanh Van Tran Minh Châu Hoàng Ngọc Khôi Nguyễn ##submission.copyrightStatement## 2023-05-15 2023-05-15 4 1 535 543 10.32508/stdjhs.v4i1.548 title description none g