TY - JOUR AU - Mai Duong AU - Dao Thi Thanh An AU - Lam My PY - 2020/10/23 Y2 - 2024/03/29 TI - Pancytopenia in children at hematology department, children hospital 1: clinico-haematological profiles and bone marrow examination – a case series JF - Science and Technology Development Journal: Health Sciences JA - STDJHS VL - 1 IS - 1 SE - Original research DO - https://doi.org/10.32508/stdjhs.v1i1.438 UR - http://stdjhs.scienceandtechnology.com.vn/index.php/stdjhs/article/view/438 AB - Objectives: To determine causes of pancytopenia in children via bone marrow aspiration at Hematology Department, Children hospital 1; clinical characteristics, time to diagnostic; peripheral blood smear and bone marrow examination.Sample: Children with pancytopenia and bone marrow examination performed, at Hematology Department, Children hospital 1, from July 2017 to May 2018.Design: Case-series study.Results: A total of 96 patients were admitted to our department for bone marrow aspiration for pancytopenia during the study period. The most common diagnosis was hemophagocytic lymphohistiocytosis (HLH), 58.3%, followed by acute lymphoblastic leukemia with 26.0% and acute myeloid leukemia with 4.2%. The median duration of diagnosis (from first symptom to bone marrow aspiration) was 13.5 days (range, 4–31 days) in malignancy, 10.5 days in HLH (range, 4–49 days), and 13 days in aplastic anemia or bone marrow hypoplasia (range, 8–23 days). The peripheral blood smear showed blasts CA/blast in 88.0% cases with leukemia. Bone marrow aspiration showed hypocellularity in 10.4%, normocellularity in 68.8%, hypercellularity in 20.8%.Conclusions: In our hospital the most common causes of pancytopenia were hemophagocytic lymphohistiocytosis followed by acute leukemia. Routinely following a panel of screening tests to all children with newly pancytopenia, including complete blood cell count and peripheral blood smear is recommended. Bone marrow aspiration should be considered early. A definitive diagnosis could be made based solely on a single bone marrow aspiration in a significant fraction of cases in pediatric pancytopenia; some cases may require clinical follow-up and/or repeat bone marrow aspiration/biopsy for definitive diagnosis. ER -